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Open systems were the first to dominate the Spanish market, but disposable e-cigarettes quickly took over before the summer of 2022

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The increased oxidative stress induced by e-cigarettes stimulates the production of reactive oxygen species (ROS) in alveolar macrophages, causing lung epithelial damage and neutrophil influx at the injury site, leading to aggravated inflammation, mucus production, destruction of alveolar cells, and airway obstruction, potentially increasing future cardiovascular risks [53, 54]

But while marijuana arrests have drastically dropped since then, racial disparities remain