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It is well distributed throughout the region of western New South Wales and is considered a problem in drier, inland regions in the southern parts of the country 2 (Fig 3)

Well, the most obvious method is to stop the users smoking in the first place - but that isnt likely to happen

The proportion of pupils who thought it was OK for someone of their age to try smoking to see what it is like has steadily decreased from more than half in 1999 to around a third in 2010

Accordingly, substituting the acidic and polar residues surrounding the degraders sulfinic group with nonpolar amino acids, as well as substituting adjacent T63 with a negatively charged aspartic acid, attenuated this activity (Fig