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The nicotine content of Juul devices and similar competitor devices, which use a pod-based system, are much higher than the legal limits in the UK and EU (Juul pods in the US contain up to 5% nicotine - the legal limit in the UK is 2%), which may be one of the reasons e-cigarette use is might higher among teens and young people in the US

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While these results offer strong in vitro preclinical evidence supporting a model wherein menthol-flavored E-liquid exposure can ultimately provoke the release of EVs from BC cells capable of promoting urothelial cell transformation, they also highlight many areas that warrant further study