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Nicotine has been demonstrated to affect the structure of nAChRs in esophageal keratinocyte culturing by dislodging the regional neurotransmitter Ach

[46] Type of substance was the primary predictor of transition from drug-induced psychosis to schizophrenia, with highest rates associated with cannabis (6 studies, 34%, CI 25%46%), hallucinogens (3 studies, 26%, CI 14%43%) and amphetamines (5 studies, 22%, CI 14%34%)

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