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Conversely, at least 14 days should be allowed after stopping bupropion hydrochloride extended-release (SR) tablets before starting an MAOI antidepressant [see Contraindications (4), Drug Interactions (7.6)]

Respir Res 2013;14:97

These blockages reduce blood flow - this means the heart needs to pump faster, which leads to increased blood pressure, increasing the risk of heart attack and other heart disease