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Recurrent tobacco use resulting in a failure to fulfill major role obligations at work, school, or home (e.g interference with work) Continued tobacco use despite having persistent or recurrent social and interpersonal problems caused or exacerbated by the effects of tobacco (e.g arguments with others about tobacco use) Important social, occupational, or recreational activities are given up or reduced because of tobacco use

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Vehicles, equipment, footwear and other goods arriving at the Canadian border that are contaminated with soil are usually refused entry

The two-star relationship remained consistent in our sensitivity analysis in which we subset the input data to observations of never smokers only (Extended Data Fig