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Systemic IL-33 produced by keratinocytes synergizes with intestinal IL-25 to drive the expansion and activation of intestinal Type 2 innate lymphoid cells (ILC2s) that produces IL-4 and IL-13, which increases the number of mucosal MCs in the intestine (Leyva-Castillo et al., 2019)

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They come pre-filled with e-liquid and are thrown away when the e-liquid is used up