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In addition, acrolein adduct to reactive cysteine residues in the active center of function proteases to inhibit their activation such as tyrosine phosphatases and caspases, which interrupts the normal cellular signaling cascades and induces necrotic and apoptotic cell death (Takeuchi et al., 2001

We have added a paragraph describing our rationale for including both adult and pediatric patients to our section "Stage 2: Identifying relevant studies" 2

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Because of this dependence, smokers feel a constant need to smoke to avoid withdrawal symptoms such as irritability and anxiety