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Based on a review of 79 prospective studies, It was found that exposure to pre- or postnatal passive smoke exposure was associated with a 30% to 70% increased risk of incident wheezing (strongest effect from postnatal maternal smoking on wheeze in children aged # 2 years, Odds Ratio (OR) = 1.70, 95% CI = 1.242.35, 4 studies) and a 21% to 85% increase in incident asthma (strongest effect from prenatal maternal smoking on asthma in children aged # 2 years, Odds Ratio (OR) = 1.85, 95% CI = 1.352.53, 5 studies)

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Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells