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Moreover, e-cigarette use significantly reduces lung function in asthma patients (reduced FEV 1 /FVC ratio and peak expiratory flow (PEF)), and increases the fraction of exhaled nitric oxide (FeNO) and the pH of exhaled breath condensate (EBC) by 3.60 ppb ( p = 0.001) and 0.15 ( p = 0.014), respectively [75]

Frequency of e-cigarette use, health status, and risk and protective health behaviors in adolescents

Second, the study design was cross-sectional, which precluded the establishment of causal relationships

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