toxins in cigarette smoke Chemicals Tobacco Products and Your Health Mayo Clinic Q and A:

ROS cause oxidative stress, which damages cellular proliferation, metabolism, and health, and can be involved in the development of several cardiovascular (e.g., atherosclerosis), respiratory (e.g., chronic obstructive pulmonary disease, asthma), and neurodegenerative disorders (e.g., Parkinsons disease, multiple sclerosis) as well as diabetes, rheumatoid arthritis, and some types of cancers (e.g., lung, colorectal) (Domej et al., 2014

Both onstage and off, he appears to be just barely able to contain his prodigious energy

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The body cant clear these fibers, so they can stay there for decades, slowly damaging DNA and triggering the cell mutations that lead to cancer