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Ive smoked on & off for eight years, since I was 19, but usually in the range of 1-4 cigarettes a day, almost exclusively when writing (at social gatherings as well, yes)

Repeated irritation from these actions can lead to the thickening of the mucosal lining, resulting in leukoplakia patches

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NF-B [edit] In long-term smoking or established diseases, not only does CSE decrease the production of pro-inflammatory cytokines, but also impairs TLR2 and TLR4 signaling