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The National Health and Medical Research Council (NHMRC) has issued a policy statement on smoke inhalation procedures in mice and rats, recommending that: Due to the significant adverse impacts of the nose-only exposure procedure on animal wellbeing and the potential confounding effects of these impacts on scientific outcomes, the use of this procedure can no longer be justified in accordance with the Australian code for the care and use of animals for scientific purposes and its use must be phased out as soon as practicable. The nose-only method is a contentious research method used by a research group at the Centenary Institute, Sydney, in which mice are constrained in a tube and attached to a smoking machine, where they are forced to smoke up to 12 cigarettes twice a day for up to 18 weeks before being killed to measure disease indicators