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CRL4 is involved in regulating the level of p53 to determine whether p53 induces growth arrest during spermatogenesis (42)

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The virus can spread in three main ways: Direct skin or mucous-membrane contact with an active sore (a cold sore on the lip is the classic example) Saliva contact, particularly during an active outbreak or in the hours before a lesion appears Asymptomatic shedding, where the virus is present in saliva even when no sore is visible Within this framework, shared cups and utensils become a plausible (though minor) route, and only under specific conditions