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Belt, Cherokee Language Instructor: The removal had caused the deaths of some four thousand people

Although the underlying mechanisms by which arsenic causes such oxidative damage are not yet fully understood, possible mechanisms could include inhibition of antioxidant enzymes such as superoxide dismutase (SOD) and catalase, interface with cellular antioxidant defense systems by reducing levels of intracellular antioxidants such as glutathione, inhibition of DNA repair mechanisms, and alterations in epigenetic processes [7]

Their conclusions, presented in a 387-page report, were that cigarette smoking is a major cause of lung cancer, throat cancer and chronic bronchitis

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