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However, the development of a dense white plaque or erythema may signal transformation to malignancy and these areas should be biopsied

10.1080/146222003100073676 Haustein K-O, Krause J, Haustein H, Rasmussen T, Cort N: Effects of cigarette smoking or nicotine replacement on cardiovascular risk factors and parameters of haemorheology

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Rather, CMS may use its discretion to reduce the weight of the ACPT in the three-way blend in accordance with 425.652(b)(4)(ii) if CMS determines that the SAHS billing activity represents an unforeseen circumstance that warrants a reduction to the weight