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Long-term smoking can result in reduction of bone density [67], degeneration of bone microstructure, and increased bone fragility [66]

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These results suggest that smoking may worsen the severity of the disease and prolong the disease course and drug treatment with immunosuppressants

In the meantime, the e-cigarette market exploded and, driven by flavored products, youth usage of e-cigarettes began to increase, from 1.5% of high school students in 2011 to 16% in 2015