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In order to be enrolled in the clinical trial, smokers had to be motivated to quit

Obesity is considered one of the important risk factors for this disease, possibly through systemic inflammation (216)

Surprisingly, the implementation of increased rules and regulation has done little to slow the efforts of tobacco advertisements, as since 1981, as cigarette consumption in the United States have declined, tobacco industry expenditure on advertising and promotion have grown 10 times greater.[4] Even though the general public understands the health effects of cigarettes, these companies push even harder to lure in potential customers, and maintain current sales levels