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First described in neuronal cell death, oxidative stress induced by both neuronal excitotoxicity 29 and smoke exposure 13,16,17 leads to PARP-1 activation and initiation of the parthanatos pathway

doi:10.1093/ntr/ntx028 101

Carcinogens in cigarette smoke can directly mutate tumor suppressor genes and oncogenes, while cigarette smoke-induced inflammation creates a tumor-promoting microenvironment in the lungs