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Concept flavors pose a challenge for enforcement of flavored tobacco restrictions, as they make it difficult for enforcement agencies to determine whether a tobacco product meets the legal definition of a flavored tobacco product

Out of the 365 SNPs, 133 (36.4%) were confirmed to be associated with smoking initiation in GERA, including 14 at a Bonferroni-corrected alpha level of 1.37 10 4 (0.05/365) (Supplementary Data 1)

Whether women in the cohort would have found smoking cessation more difficult than men is difficult to assess

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