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In multivariate models, variable selection was performed using the adaptive Lasso (Least Absolute Shrinkage and Selection Operator) 22 method, a penalized regression approach that assigns variable-specific weights, allowing for more efficient selection of relevant predictors

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Giovannucci Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Journal ranking: Q1 Key takeaways: Cigarette smoking is strongly associated with an increased risk of colorectal cancer, with up to one in five cancers in the United States potentially attributable to tobacco use