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The new cigarette health warnings complement other critical FDA actions, including outreach campaigns targeted to both adults and youth, to educate the public about the dangers associated with using cigarettes, as well as other tobacco products. The proposed warnings feature color images and describe the health risks of smoking, warning, Smoking reduces blood flow to the limbs, which can require amputation, and Smoking causes bladder cancer, which can lead to bloody urine. Various health groups the American Academy of Pediatrics, the American Cancer Society, the American Cancer Society Cancer Action Network, the American Heart Association, the American Lung Association, the Campaign for Tobacco-Free Kids and the Truth Initiative responded to the final rule in a written statement

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[72] These early systems were generally inefficient at delivering nicotine, in part because the particle sizes of the aerosol were too large to penetrate deep into the lungs