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Cabozantinib, a tyrosine kinase inhibitor that includes AXL, has been reported to reverse EMT-associated osimertinib resistance in NSCLC [191]

Additionally, in head and neck cancer stem cells cisplatin resistance can be modulated by RXR through CTR1 expression 70

Rapid Onset: Symptoms of nicotine poisoning can manifest quickly, within minutes to hours after exposure, depending on the amount of nicotine absorbed and the individual's sensitivity

Furthermore, cigarette smoke exposure increases a host susceptibility to pathogen infection through disrupting the secretion of antimicrobial peptides already in nasal epithelium