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60 May 10, 2021 The FDA published the final PMTA rule: Premarket Tobacco Product Applications and Recordkeeping Requirements. This rulebook was published seven months after the deadline for submitting PMTAs for products already on the market as of August 8, 2016

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Additional evidence on harms from e-cigarette use (whether used for tobacco cessation or not) considered by the USPSTF included data of the 2019 EVALI outbreak in the US 53 and the 2018 report Public Health Consequences of E-Cigarettes by the National Academies of Sciences, Engineering, and Medicine

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