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There were 15 studies on the use of nicotine replacement [19, 20, 22,23,24, 29,30,31,32,33,34,35, 90,91,92], and four of 14 studies showed that smoking cessation did not alter circulating NOx levels [92], improved the function of EPCs but not the number of EPCs [24], did not improve FMD [91], and improved FMD but not RHI [34]

After detox, evidence-based therapies help individuals build skills for long-term recovery and relapse prevention

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