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These results demonstrate that hotspot formation in Latin America and the Caribbean is mostly widespread in South America, and recurrent across multiple coastal systems, reflecting strong local variability yet consistently high contamination levels in several countries

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Each Monograph presents a description of a carcinogenic agent and how people are exposed, critical overviews of the epidemiological studies and animal cancer bioassays, and a concise review of the agent's toxicokinetics, plausible mechanisms of carcinogenesis, and potentially susceptible populations, and life-stages