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Puff duration and personal tolerance vary: a 2-second puff delivers less nicotine than a 5-second puff, and individuals metabolize nicotine at different rates

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Qualitative variables were analyzed using the chi-squared test, such as comparisons of data between current smokers, non-smokers, and ex-smokers, and continuous variables such as diagnosis age were analyzed using the Kruskal-Wallis test using Statistical Package for Social Sciences software (version 21.0, SPSS, IBM Corp

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