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32 In in vitro bronchial epithelial cell models, pyruvate kinase M2 (PKM2) upregulation is closely associated with enhanced inflammatory responses and EMT, whereas PKM2 knockdown significantly reduces the release of pro-inflammatory cytokines, lowers reactive oxygen species(ROS) levels, and suppresses EMT

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a 2005 survey stated that 49 } : CS1 maint: multiple names: authors list (link) "Tobacco majors Lorillard and Reynolds American near merger"