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A review of smoking cessation: potentially risky effects on prescribed medications

Mice that had been treated as adolescents with THC, but were now drug-free showed the following: Reduced fat mass and increased lean mass Partial resistance to obesity and hyperglycemia Higher-than-normal body temperature Inability to mobilise fuel from fat stores

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By stimulating catecholamine release (particularly norepinephrine), nicotine encourages the breakdown of stored fat (lipolysis) and shifts the body toward using fatty acids as an energy source