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These mechanistic interactions are summarized in Table 2 and Figure 1 , which outlines how smoking-driven immune changes parallel key features of immunosenescence and may influence MS biology

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This shift to the products that remain flavored is also evident in sales data, with the market share of disposable e-cigarettes growing from 25.0% in 2020 to 27.5% in 2021, and among disposable e-cigarettes, the market share for flavors other than tobacco, menthol or mint increased from 69.2% in 2020 to 79.4% in 2021