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Introduction In 2004, a Beijing-based company, Ruyan Group (Holdings) Ltd, China, patented and launched electronic cigarettes (e-cigarettes) also called electronic nicotine delivery systems (ENDS) ( DNA damage generated by oxidative stress has a strong mechanistic link to the pathophysiology of metabolic disease ( NAD+ homeostasis is regulated by nutrient-sensing signaling pathways, which play key roles in metabolism and survival