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Your brains mesolimbic pathway becomes hijacked, prioritizing nicotines rewards over natural pleasures Your dopamine receptors gradually desensitize, requiring more nicotine to achieve the same effect Your neural circuits reshape themselves, making you increasingly vulnerable to cravings and relapse The systems adaptation involves multiple feedback mechanisms, including MAO inhibition and receptor desensitization

This again, is another sign of marginalization from the existing normal culture

Mate for example here means friend usually a male

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