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Arterioscler Thromb Vasc Biol 41(2):839853 Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL et al (2019) Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice

By Market & Regional Variation Cigarette cartons are configured differently according to country-specific regulations and market demands: United States: 10 packs 20 cigarettes = 200 total Australia: 10 packs 2526 cigarettes = 250260 total Europe: Varies by country (plain packaging laws in some regions) Duty-Free Markets: Often 20-pack cartons (400 cigarettes) By Promotional & Seasonal Purpose Cigarette brands frequently modify carton configurations for: Promotional campaigns adding an extra pack to attract customers Seasonal offers holiday-themed packaging with special finishes Discount bundles larger cartons with reduced per-pack pricing Limited editions collector-style packaging with unique designs These promotional cigarette cartons serve as powerful marketing tools that drive brand visibility and customer engagement

While measures taken since the FCTC came into force in 2005 have reduced the percentage of smokers from 28% of the total population in 2000 to 16.3% in 2020, these achievements are threatened by novel tobacco and nicotine products