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The authors stated that the majority of mainstream constituents of THS 2.2 were reduced compared to 3R4F . Specifically, they found that compared with the 3R4F reference cigarette, THS 2.2 produced more than 90% fewer HPHCs [harmful and potentially harmful constituents ] , except for carbonyls, ammonia, and NAB [N-nitrosoanabasine], which were about 5080% lower. The authors cautioned that reduction of harmful constituent emissions cannot be interpreted as equivalent to a proportionate harm/risk reduction for smokers. Japanese Department of Environmental Health This department is a branch of the Japanese National Institute of Public Health (NIPH), member of the WHO TobLabNet

& Phillips, L