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Once punctured, discard any unused solution after 28 days

The question of whether a very low-dose COC used continuously or progestin monotherapy is better may be of little relevance, and it is plausible that ensuring amenorrhoea is more important than the modality chosen to achieve these goals [65]

Moreover, these mentioned characteristic alterations are inter-related, with bi-directional feedback, for example, high proliferation rate of growing solid tumor mass would exhaust the local supply of O 2 sooner