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A 2016 study in the Journal of the American Medical Association found that prescription medications and nicotine replacement therapy were equally effective: After one year, about 20 percent of participants in both groups stopped smoking

While transient activation of NRF2 during acute oxidative stress is well established, how NRF2 activity is maintained under chronic cigarette exposure remains poorly understood

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Centers for Disease Control and Prevention: How Quit Smoking Medications Work Cleveland Clinic: Want to Quit Smoking