Furthermore, in a randomized, double-blind, placebo-controlled study enrolling 70 patients with AD aged 6 to 12 years, the administration of melatonin (6 mg daily) demonstrated to improve SCORAD ( p = 0.007), objective SCORAD ( p = 0.001), serum total IgE levels ( p = 0.005) and Childrens Sleep Habits Questionnaire scores ( p = 0.006) at 6 weeks (40)
EVIDENCE OF ABNORMAL BRAIN CONNECTIVITY IN ASD It is apparent from many studies that ASD involves the loss of critically important neuronal connections and networks (Just et al
CuP demonstrates a wide range of biological activities, including antioxidative properties, inflammatory modulation, chemotactic cell recruitment, and promotion of angiogenesis and cell proliferation 35,36
doi: 10.1038/srep46288 63 BurtscherMBrunnerFFaulhaberMHotterBLikarR