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A large number of clinical trials have been carried out to evaluate the combination regimens of c-Met inhibitors, anti-PD1 agents, and other drugs in the treatment of malignant tumors

Although thyroid hormone production in follicular cells is iron-dependent, iron overloadresulting from hepcidin-mediated ferroportin blockade, macrophage-derived ferritin uptake, and heme catabolismand resultant oxidative stress can trigger their degeneration through the ferroptosis pathway (179)

Lilius G, Persson M, Bulow L, Mosbach K

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