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An analysis of WES or WGS data from 5,243 cancers of various types often associated with smoking demonstrated an increased burden of somatic mutations and several distinct mutational signatures in tumours from patients with a history of tobacco smoking, with total base substitutions nearly fivefold higher in LUADs from such patients compared with LUADs from patients who have never smoked 40

Accordingly, among the common ferroptosis-inducing agents, only parts of them are inhibited by ALOX depletion

Front Immunol 13:1075260 Cools-Lartigue J, Spicer J, McDonald B, Gowing S, Chow S, Giannias B, Bourdeau F, Kubes P, Ferri L (2013) Neutrophil extracellular traps sequester Circulating tumor cells and promote metastasis

The use of 1H spin echo NMR and HPLC to confirm doxorubicin induced depletion of glutathione in the intact HeLa cell