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On this basis, this review comprehensively examines the role of ferroptosis in NDDs and explores the mechanisms through which exercise modulates ferroptosis to alleviate NDD pathology, thereby providing a scientific foundation for exercise-based brain health interventions

Mechanistic Research Perspective Modulation of cellular signaling pathways Regulation of gene expression patterns in molecular research models Influence on mitochondrial metabolic activity Interaction with enzymatic activation systems Peptide-mediated cellular communication studies Primary Research Applications Cellular and Molecular Biology Studies: Used to explore peptide-mediated signaling behavior and intracellular regulatory mechanisms

The GH/IGF-1 axis is highly sensitive to small changes in GH or IGF-1 2 levels, which can trigger feedback suppression or amplify downstream effects

Funding NS acknowledges the Science & Engineering Research Board and the University Grants Commission, Govt