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The study protocol was approved by the Chung-Ang University Hospital Institutional Review Board (IRB number 1600-002-253) and the Seoul National University Hospital Institutional Review Board (IRB number 1608-163-788)

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Moreover, FACS analysis of splenocytes from Sema4d +/+ wild-type mice showed that 100% of CD8 + T cells are Sema4D + , while in Sema4d / mice, no Sema4D could be detected (Supplementary Fig