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Cardiovascular and Laboratory Parameters: No clinically significant changes were observed in blood pressure, heart rate, ECG readings, or standard laboratory values including liver and kidney function tests

This lack of significant improvement may be attributed to the activation of VEGF-independent angiogenic pathways, the recruitment of proangiogenic stromal cells, the induction of vasculogenesis or even the dose of the antiangiogenic agent used, which may reduce the size of blood vessel pores, further obstructing the delivery of this antibody [30, 39, 40]

The appropriate dosage of TB-500 can vary significantly depending on the individuals condition, therapeutic goals, and the treatment plan prescribed by a licensed medical professional

Which reduces its practicality for medical injections, especially with multiple-use medications