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220 In the human hepatocyte-derived Huh-7 cell line, treatment with GC-1 upregulated the transcription of mitochondrial carnitine palmitoyl transferase 1a (CPT1a), which is part of a mitochondrial outer membrane fatty acid transfer complex, with a dose-response comparable to that of the native THR ligand, triiodothyronine (T3)

The transition from the lab to testing in humans is one of the most important steps in drug development

regarding knee OA [33], underlines the need for standardized approaches