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Its established mechanism of action continues to support mechanistic investigations into nicotinamide methylation pathways and the broader role of NNMT within cellular regulatory networks.

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NNMT metabolizes nicotinamide into 1-methylnicotinamide (MNA), diverting it away from the NAD+ salvage pathway

NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics