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Reference: FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation

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Clinical cohort studies confirm that cerebrospinal fluid levels of lipid peroxidation markers (e.g., MDA, 8-OHdG) are significantly elevated in APOE4 carriers compared to APOE2 carriers, exhibiting a strong positive correlation with the rate of hippocampal atrophy (199)