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These can be the upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, altered NMDA receptor expression, altered dendritic morphology [167,168], and altered functioning of cholinergic (ACh-ergic) basal neurons, projecting to the cortex [169] by repeated exposure to amphetamine (amphetamine-induced sensitization)

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This combination is supposed to offer the following potential benefits: Vitamin B12 may help mitigate nausea, fatigue, and general weakness, which are common side effects of semaglutide