As a regulator of the pineal gland, Epitalon may help in the modulation ofmelatonin secretion, improving sleep patterns and circadian rhythm regulation
Actions of VIP in the body include: Vasodilation to assist in blood pressure regulation, GI tract epithelial cell secretion and blood flow increasing water and electrolytes in the GI tract, relaxation of intestinal smooth muscle, exerting a positive effect on hypothalamic kisspeptin neurons, hormone balancing, and aromatase inhibiting effect corrects estradiol, 25-OH Vitamin D, and testosterone in males, downregulation of th1 responses and controlling cytokine responses to restore immunoregulation, especially following infections by intracellular bacteria and viruses
According to their findings, ADSCs induced into senescence by carboplatin or olaparib (a drug used in ovarian cancer therapy) promoted the development and migration of ovarian cancer cells [117]
[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects
