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Wang M, Huang Z, Li X et al (2024) Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300/H3K27ac/PLK1 axis

J Pediatr Adolesc Gynecol 27(6):342346 Osen A, Stefoski D, Shoemaker T, Kaplan T, Morales FS (2023) Cyclophosphamide for severe acute forms of central nervous system inflammatory disorders

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COMT is involved in converting 2-hydroxyestradiol (an antiestrogen) to 2-methoxyestradiol (proestrogen), creating a hyper-estrogenic milieu due to the decrease in antiestrogen and an increase in proestrogen