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In fact, 10 out of the total 15 clinical trials performed to date in SCA3 are either open label or lack a placebo arm (Table 2) [174]

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These longer cycles require more careful monitoring and may benefit from slight dose reductions in weeks 13-16 to maintain receptor sensitivity

published in Frontiers in Physiology confirmed that BPC-157 dose- and time-dependently increased GHR expression in isolated rat Achilles tendon fibroblasts at both mRNA and protein level, and that GH added to BPC-157-treated fibroblasts produced significant, dose-dependent increases in cell proliferation establishing GHR upregulation as a specific molecular mechanism through which BPC-157 enhances local tissue sensitivity to growth hormone signalling