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Nrf2 is a crucial oxidative-stress-responsive transcription factor that governs the expression of antioxidants and cytoprotective genes, protecting cells against oxidative stress to maintain cellular ROS homeostasis [50]

Due to the effects of increasing antioxidant and reducing free radicals following the administration of this drug (18), the role of this drug in improving insulin secretion following the regulation of its receptor activity, reducing fat tissue, preventing and improving endothelial damage and ischemia, inhibiting phospholipid metabolism and also regulating the process of releasing pro-inflammatory cytokines has been noted (19, 20)